Archive for Mart 29th, 2024

One study reported the use of TALEN-approach to edit the β-catenin gene in mouse liver to generate an efficient and physiologic liver cancer mouse model [124]. However, both ZFNs and TALENs are nuclease-based designs that are difficult to construct and have varying targeting efficiency. The recent advent of the clustered regularly-interspaced short palindromic repeats (CRISPR)-Cas9 […]